IL-13 蛋白
(Interleukin 13 (IL13))
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008].
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Latest Publications for our IL-13 蛋白
: "Modulation of murine macrophage function by IL-13." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 12, pp. 7151-60, (1994) (PubMed).: "Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells." in: Immunology today, Vol. 15, Issue 1, pp. 19-26, (1994) (PubMed).
: "Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin." in: Journal of cellular physiology, Vol. 140, Issue 2, pp. 323-34, (1989) (PubMed).
Aliases for IL-13 蛋白
interleukin 13 (IL13) 蛋白interleukin 13 (Il13) 蛋白
IL-13 蛋白
Il-13 蛋白
IL13 蛋白
L13 蛋白
P600 蛋白
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