(Insulin-Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2))
This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Rivera Vargas, Boudoukha, Simon, Souidi, Cuvellier, Pinna, Polesskaya: "Post-transcriptional regulation of cyclins D1, D3 and G1 and proliferation of human cancer cells depend on IMP-3 nuclear localization." in: Oncogene, Vol. 33, Issue 22, pp. 2866-75, (2014) (PubMed).
Schaeffer, Hansen, Morris, LeBoeuf, Abrass: "RNA-binding protein IGF2BP2/IMP2 is required for laminin-?2 mRNA translation and is modulated by glucose concentration." in: American journal of physiology. Renal physiology, Vol. 303, Issue 1, pp. F75-82, (2012) (PubMed).
Boudoukha, Cuvellier, Polesskaya: "Role of the RNA-binding protein IMP-2 in muscle cell motility." in: Molecular and cellular biology, Vol. 30, Issue 24, pp. 5710-25, (2010) (PubMed).
Zeggini, Weedon, Lindgren, Frayling, Elliott, Lango, Timpson, Perry, Rayner, Freathy, Barrett, Shields, Morris, Ellard, Groves, Harries, Marchini, Owen, Knight, Cardon, Walker, Hitman, Morris, Doney et al.: "Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. ..." in: Science (New York, N.Y.), Vol. 316, Issue 5829, pp. 1336-41, (2007) (PubMed).