This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011].
Tervaniemi, Katayama, Skoog, Siitonen, Vuola, Nuutila, Sormunen, Johnsson, Linnarsson, Suomela, Kankuri, Kere, Elomaa: "NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis." in: Scientific reports, Vol. 6, pp. 22745, (2016) (PubMed).
Anthonio, Brees, Baumgart-Vogt, Hongu, Huybrechts, Van Dijck, Mannaerts, Kanaho, Van Veldhoven, Fransen: "Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6." in: BMC cell biology, Vol. 10, pp. 58, (2009) (PubMed).
Aliases for IFI16 抗体
interferon gamma inducible protein 16 (IFI16) 抗体 interferon induced transmembrane protein 2 (Ifitm2) 抗体 myeloid cell nuclear differentiation antigen-like protein (LOC100156073) 抗体 interferon-activable protein 203 (LOC488622) 抗体 interferon gamma inducible protein 16 (Ifi16) 抗体 IFI16 抗体 Ifitm3l 抗体 Ifitml 抗体 IFNGIP1 抗体 PYHIN2 抗体