HYOU1 产品
(Hypoxia Up Regulated 1 (HYOU1))
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The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. [provided by RefSeq, Oct 2008].
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Featured HYOU1 Categories
HYOU1 抗体
High quality antibodies with extensive validation data.
HYOU1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
HYOU1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HYOU1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), ICC
Validations
- (8)
Cat. No.
ABIN2855339
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (3)
- (4)
Cat. No.
ABIN564589
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (1)
- (2)
Cat. No.
ABIN705851
Quantity
100 μL
Datasheet
Datasheet
Recommended HYOU1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967510
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960602
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Cow
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN992980
Quantity
96 tests
Datasheet
Datasheet
Recommended HYOU1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307312
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307314
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7577524
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our HYOU1 Products
: "Chick Embryo: A Preclinical Model for Understanding Ischemia-Reperfusion Mechanism." in: Frontiers in pharmacology, Vol. 9, pp. 1034, (2018) (PubMed).: "Expression and function of HSP110 family in mouse testis after vasectomy." in: Asian journal of andrology, Vol. 19, Issue 3, pp. 355-361, (2016) (PubMed).
: "Tetrandrine attenuated cerebral ischemia/reperfusion injury and induced differential proteomic changes in a MCAO mice model using 2-D DIGE." in: Neurochemical research, Vol. 38, Issue 9, pp. 1871-9, (2013) (PubMed).
: "Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in normal lung." in: Biochemical and biophysical research communications, Vol. 405, Issue 4, pp. 610-4, (2011) (PubMed).
: "Mechanism of cancer cell adaptation to metabolic stress: proteomics identification of a novel thyroid hormone-mediated gastric carcinogenic signaling pathway." in: Molecular & cellular proteomics : MCP, Vol. 8, Issue 1, pp. 70-85, (2009) (PubMed).
: "Proteinuria and hyperglycemia induce endoplasmic reticulum stress." in: Journal of the American Society of Nephrology : JASN, Vol. 19, Issue 11, pp. 2225-36, (2008) (PubMed).
Synonyms and alternative names related to HYOU1
hypoxia up-regulated 1 (HYOU1), hypoxia up-regulated 1 (Hyou1), hypoxia up-regulated 1 (hyou1), hypoxia up-regulated protein 1 (LOC100380749), hypoxia up-regulated 1 S homeolog (hyou1.S), AI415631, Cab140, CBP-140, GRP-170, Grp170, GRP170, HSP12A, HYOU1, id:ibd5056, ORP-150, ORP150, Orp150, orp150, wu:fd14c05, zgc:56019Protein level used designations for HYOU1
- 150 kDa oxygen-regulated protein
- 170 kDa glucose-regulated protein
- glucose-regulated protein 170
- hypoxia up-regulated protein 1
- oxygen regulated protein (150kD)
- 140 kDa Ca(2+)-binding protein
- 150-kDa oxygen regulated protein
- 170 kDa glucose regulated protein GRP170
- GRP-170
- calcium binding protein 140
- calcium binding protein, 140 kDa
- ORP-150
- hypoxia up-regulated 1
- Hypoxia up-regulated protein 1
- hypoxia up-regulated protein 1-like
- glucose regulated protein, 170 kDa
- oxygen regulated protein, 150 kDa
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