The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. Transcript variants utilizing alternative polyadenylation signals exist. [provided by RefSeq, Jul 2008].
Hooks, Audoux, Fazli, Lesjean, Ernault, Senant, Leste-Lasserre, Hagedorn, Rousseau, Danet, Branchereau, Brugières, Taque, Guettier, Fabre, Rullier, Buendia, Commes, Grosset, Raymond: "New insights into diagnosis and therapeutic options for proliferative hepatoblastoma." in: Hepatology (Baltimore, Md.), (2017) (PubMed).
Mohler, Titus, Bai, Kennerley, Lih, Tomer, Wilson: "Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer." in: Cancer research, Vol. 71, Issue 4, pp. 1486-96, (2011) (PubMed).
Muthusamy, Andersson, Kim, Butler, Waage, Bergerheim, Gustafsson: "Estrogen receptor ? and 17?-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 50, pp. 20090-4, (2011) (PubMed).
Huang, Luu-The: "Gene structure, chromosomal localization and analysis of 3-ketosteroid reductase activity of the human 3(alpha-->beta)-hydroxysteroid epimerase." in: Biochimica et biophysica acta, Vol. 1520, Issue 2, pp. 124-30, (2001) (PubMed).