In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008].
Heshmati, Kharazi, Türköz, Chang, Kamali Dolatabadi, Boström, Krstic, Boukoura, Wagner, Kadri, Månsson, Altun, Qian, Walfridsson: "The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation." in: Scientific reports, Vol. 8, Issue 1, pp. 11202, (2019) (PubMed).
Schummer, Thorpe, Giraldez, Bergan, Tewari, Urban: "Evaluating Serum Markers for Hormone Receptor-Negative Breast Cancer." in: PLoS ONE, Vol. 10, Issue 11, pp. e0142911, (2015) (PubMed).
Boucherat, Montaron, Bérubé-Simard, Aubin, Philippidou, Wellik, Dasen, Jeannotte: "Partial functional redundancy between Hoxa5 and Hoxb5 paralog genes during lung morphogenesis." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 304, Issue 12, pp. L817-30, (2013) (PubMed).
Yoo, Park, Kim, Jung, Chang: "Epigenetic inactivation of HOXA5 and MSH2 gene in clear cell renal cell carcinoma." in: Pathology international, Vol. 60, Issue 10, pp. 661-6, (2010) (PubMed).
Okada, Jiang, Lemieux, Jeannotte, Su, Zhang: "Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L." in: Nature cell biology, Vol. 8, Issue 9, pp. 1017-24, (2006) (PubMed).