The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009].
Wahyudi, Wang, McAlpine: "Dimerization of a heat shock protein 90 inhibitor enhances inhibitory activity." in: Organic & biomolecular chemistry, Vol. 12, Issue 5, pp. 765-73, (2014) (PubMed).
Willmer, Contu, Blatch, Edkins: "Knockdown of Hop downregulates RhoC expression, and decreases pseudopodia formation and migration in cancer cell lines." in: Cancer letters, Vol. 328, Issue 2, pp. 252-60, (2012) (PubMed).
Aliases for HOPX 蛋白
HOP homeobox (HOPX) 蛋白 HOP homeobox (Hopx) 蛋白 HOP homeobox (hopx) 蛋白 1110018K11Rik 蛋白 1200015P04Rik 蛋白 2300002F06Rik 蛋白 AI848177 蛋白 AW490897 蛋白 CAMEO 蛋白 Cameo 蛋白 cameo 蛋白 GIIg15b 蛋白 Hdop 蛋白 HOD 蛋白 Hod 蛋白 hod 蛋白 HOP 蛋白 Hop 蛋白 hop 蛋白 HOPX 蛋白 LAGY 蛋白 lagy 蛋白 MGC147344 蛋白 NECC1 蛋白 necc1 蛋白 OB1 蛋白 Ob1 蛋白 ob1 蛋白 Obl 蛋白 SMAP31 蛋白 smap31 蛋白 TOTO 蛋白 Toto 蛋白 toto 蛋白