Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity).
Adamska, Léger, Brand, Hadrys, Braun, Bober: "Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace." in: Mechanisms of development, Vol. 97, Issue 1-2, pp. 161-5, (2000) (PubMed).