This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde. [provided by RefSeq, Nov 2011].
Zhou, Xu, Chen, Liu, Pang, Yao, Zhang: "Stability of HIB-Cul3 E3 ligase adaptor HIB Is Regulated by Self-degradation and Availability of Its Substrates." in: Scientific reports, Vol. 5, pp. 12709, (2016) (PubMed).
Tasi, Chao, Chung, Liu, Lin, Liao, Pan, Chiang, Kuo, Lin: "Characterization of 3-hydroxyisobutyrate dehydrogenase, HIBADH, as a sperm-motility marker." in: Journal of assisted reproduction and genetics, Vol. 30, Issue 4, pp. 505-12, (2013) (PubMed).