Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
Schiffer, Letzian, Jost, Mladenov, Hristodorov, Huhn, Fischer, Barth, Thepen: "Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells." in: Cancer letters, Vol. 341, Issue 2, pp. 178-85, (2013) (PubMed).
Aliases for GZMM 抗体
granzyme M (LOC100136381) 抗体 granzyme M (GZMM) 抗体 granzyme M (Gzmm) 抗体 granzyme M (lymphocyte met-ase 1) (Gzmm) 抗体 LMET1 抗体 Lmet1 抗体 MET1 抗体 MMET-1 抗体