(G Protein-Coupled Receptor 37 (Endothelin Receptor Type B-Like) (GPR37))
This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012].
Yang, Nishimura, Imai, Takahashi, Lu: "Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila." in: Neuron, Vol. 37, Issue 6, pp. 911-24, (2003) (PubMed).
Imai, Soda, Hatakeyama, Akagi, Hashikawa, Nakayama, Takahashi: "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity." in: Molecular cell, Vol. 10, Issue 1, pp. 55-67, (2002) (PubMed).
Imai, Soda, Inoue, Hattori, Mizuno, Takahashi: "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin." in: Cell, Vol. 105, Issue 7, pp. 891-902, (2001) (PubMed).