This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012].
Sachs, Robinson, Andres Martin, Webster, Gilbert, Lo, Rafii, Ng, Seandel: "Evaluation of candidate spermatogonial markers ID4 and GPR125 in testes of adult human cadaveric organ donors." in: Andrology, Vol. 2, Issue 4, pp. 607-14, (2014) (PubMed).
Seandel, James, Shmelkov, Falciatori, Kim, Chavala, Scherr, Zhang, Torres, Gale, Yancopoulos, Murphy, Valenzuela, Hobbs, Pandolfi, Rafii: "Generation of functional multipotent adult stem cells from GPR125+ germline progenitors." in: Nature, Vol. 449, Issue 7160, pp. 346-50, (2007) (PubMed).