GPBAR1 抗体
(G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
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Latest Publications for our GPBAR1 抗体
: "Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness." in: Biochimica et biophysica acta. Bioenergetics, Vol. 1859, Issue 9, pp. 958-974, (2018) (PubMed).: "TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease." in: Immunology, Vol. 139, Issue 1, pp. 19-29, (2013) (PubMed).
: "Plasma bile acids are associated with energy expenditure and thyroid function in humans." in: The Journal of clinical endocrinology and metabolism, Vol. 97, Issue 2, pp. 535-42, (2012) (PubMed).
: "Activation of the bile acid receptor GPBAR1 protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs and aspirin in mice." in: British journal of pharmacology, Vol. 168, Issue 1, pp. 225-37, (2012) (PubMed).
: "The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice." in: Gastroenterology, Vol. 144, Issue 1, pp. 145-54, (2012) (PubMed).
: "The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis." in: PLoS ONE, Vol. 6, Issue 10, pp. e25637, (2011) (PubMed).
Aliases for GPBAR1 抗体
G protein-coupled bile acid receptor 1 (GPBAR1) 抗体G protein-coupled bile acid receptor 1 (Gpbar1) 抗体
G protein-coupled bile acid receptor 1 S homeolog (gpbar1.S) 抗体
BG37 抗体
GPBAR1 抗体
Gpbar1 抗体
GPCR 抗体
GPCR19 抗体
GPR131 抗体
M-BAR 抗体
MGC84403 抗体
TGR5 抗体
Tgr5 抗体
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