电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

GP1BB 产品

(Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))
Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described\; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene. [provided by RefSeq, Dec 2010].

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured GP1BB Categories

GP1BB 抗体

High quality antibodies with extensive validation data.

GP1BB ELISA试剂盒

Reliable ELISA kits for a wide range of species.

GP1BB 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GP1BB 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (5)
Cat. No. ABIN7439282
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IHC (p)
Validations
  • (3)
Cat. No. ABIN604880
Quantity 50 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (2)
Cat. No. ABIN7440488
Quantity 100 μL
Datasheet Datasheet

Recommended GP1BB ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6956264
Quantity 96 tests
Datasheet Datasheet

Recommended GP1BB 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7274757
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7274756
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123168
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our GP1BB Products

Nygaard, Herfindal, Asrud, Bjørnstad, Kopperud, Oveland, Berven, Myhren, Hoivik, Lunde, Bakke, Døskeland, Selheim: "Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression." in: Scientific reports, Vol. 7, Issue 1, pp. 8725, (2019) (PubMed).

Synonyms and alternative names related to GP1BB

glycoprotein Ib (platelet), beta polypeptide (GP1BB), glycoprotein Ib platelet beta subunit (GP1BB), glycoprotein Ib platelet beta subunit (Gp1bb), glycoprotein Ib, beta polypeptide (Gp1bb), BDPLT1, BS, CD42C, GPIBB

Protein level used designations for GP1BB

  • glycoprotein Ib (platelet), beta polypeptide
  • GP-Ib beta
  • antigen CD42b-beta
  • nuclear localization signal deleted in velocardiofacial syndrome
  • platelet glycoprotein Ib beta chain
  • GPIb-beta
  • GPIbB
  • glycoprotein Ib, beta polypeptide
You are here:
客服