(Golgi Reassembly Stacking Protein 2, 55kDa (GORASP2))
This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
Subramanian, Capalbo, Iyengar, Rizzo, di Campli, Di Martino, Lo Monte, Beccari, Yerudkar, Del Vecchio, Glielmo, Turacchio, Pirozzi, Kim, Henklein, Cancino, Parashuraman, Diviani, Fanelli, Sallese et al.: "Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum. ..." in: Cell, Vol. 176, Issue 6, pp. 1461-1476.e23, (2019) (PubMed).
Roghi, Jones, Gratian, English, Murphy: "Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen." in: The FEBS journal, Vol. 277, Issue 15, pp. 3158-75, (2010) (PubMed).