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The levels of antibodies reactive with SPRASA were elevated in infertile women.
SLLP1 represents a promising target for the immunotherapy of multiple myeloma.
Authors present evidence that the variants could affect the expression levels or function of SPRASA, thereby affecting a couple's fertility.
SLLP1 could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane
SLLP1 is capable of eliciting B-cell immune responses in vivo in cancer-bearing individuals.
distinct from c-lysozyme by substituting two essential catalytic residues (E35T/D52N), and by forming helical filaments approximately 75 A in diameter with a 25 A central pore comprised of six monomers per helix turn repeating every 33 A
Female mice immunized with SPRASA had profound infertility following timed matings and those mice that did become pregnant had reduced fetal viability.
Data show that SAS1B/SAS1R (Sperm Acrosomal SLLP1 Binding/Sperm Acrosomal SLLP1 receptor) bound to sperm acrosomal protein SlLP1 with high affinity.
This study demonstrates the retention of mouse sperm lysozyme-like protein (mSLLP1) in the equatorial segment of spermatozoa following the acrosome reaction and a role for mSLLP1 in sperm-egg binding and fertilization.
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro (By similarity).
cancer/testis antigen 54
, lysozyme-like acrosomal sperm-specific secretory protein ALLP-17
, lysozyme-like protein 3
, lysozyme-like sperm-specific secretory protein ALLP17
, sperm acrosome membrane-associated protein 3
, sperm lysozyme like protein 1
, sperm lysozyme-like protein 1
, sperm protein reactive with ASA
, sperm protein reactive with antisperm antibodies
, acrosomal sperm protein
, sperm c-type lysozyme-like protein
, sperm lysozyme-like protein 1 precusor
, Sperm protein reactive with ASA
, Sperm protein reactive with antisperm antibodies