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Glypican 3 产品

(Glypican 3 (GPC3))
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].

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Featured Glypican 3 Categories

Glypican 3 抗体

High quality antibodies with extensive validation data.

Glypican 3 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

Glypican 3 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Glypican 3 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, FACS, IHC, ELISA, ICC
Validations
  • (2)
  • (7)
Cat. No. ABIN969523
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, ICC, IP
Validations
  • (6)
Cat. No. ABIN7442228
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Rat
Application IF, FACS, IHC, StM
Validations
  • (6)
Cat. No. ABIN6939525
Quantity 100 μg
Datasheet Datasheet

Recommended Glypican 3 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (7)
  • (1)
Cat. No. ABIN6956276
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (4)
  • (1)
Cat. No. ABIN6973977
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967170
Quantity 96 tests
Datasheet Datasheet

Recommended Glypican 3 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7274774
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7274772
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7274775
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Glypican 3 Products

Berman, Kelada, Gutsche, Natarajan, Swenson, Fu, Hong, Ho, Choyke, Escorcia: "In Vitro Performance of Published Glypican 3-Targeting Peptides TJ12P1 and L5 Indicates Lack of Specificity and Potency." in: Cancer biotherapy & radiopharmaceuticals, (2019) (PubMed).

Ma, Wang, Liu, Chen, Wu, Li, Mi, Hu, Chen, Zhao: "Development and in vitro study of a bi-specific magnetic resonance imaging molecular probe for hepatocellular carcinoma." in: World journal of gastroenterology, Vol. 25, Issue 24, pp. 3030-3043, (2019) (PubMed).

Fisher, Linder, Bentzer: "Elevated plasma glypicans are associated with organ failure in patients with infection." in: Intensive care medicine experimental, Vol. 7, Issue 1, pp. 2, (2019) (PubMed).

Zhou, Shang, Yu, Tian: "Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment." in: Medicinal research reviews, Vol. 38, Issue 2, pp. 741-767, (2018) (PubMed).

Han, Ma, Zhao, Zhao, Batista, Zhou, Zhou, Yang, Wang, Bi, Xia, Bai, Garkavtsev, Zhang: "Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer." in: Oncotarget, Vol. 7, Issue 28, pp. 44406-44416, (2018) (PubMed).

Hu, Cheng, He, Wei, Wu, Meng: "Autophagy suppresses proliferation of HepG2 cells via inhibiting glypican-3/wnt/β-catenin signaling." in: OncoTargets and therapy, Vol. 11, pp. 193-200, (2018) (PubMed).

DAvola, Villacorta-Martin, Martins-Filho, Craig, Labgaa, von Felden, Kimaada, Bonaccorso, Tabrizian, Hartmann, Sebra, Schwartz, Villanueva: "High-density single cell mRNA sequencing to characterize circulating tumor cells in hepatocellular carcinoma." in: Scientific reports, Vol. 8, Issue 1, pp. 11570, (2018) (PubMed).

Wang, Chen, Chen, Sun, Li, Liu: "Elevated GPC3 level promotes cell proliferation in liver cancer." in: Oncology letters, Vol. 16, Issue 1, pp. 970-976, (2018) (PubMed).

Alyoussef, Al-Gayyar: "Cytotoxic and partial hepatoprotective activity of sodium ascorbate against hepatocellular carcinoma through inhibition of sulfatase-2 in vivo and in vitro." in: Biomedicine & pharmacotherapy, Vol. 103, pp. 362-372, (2018) (PubMed).

Cartier, Indersie, Lesjean, Charpentier, Hooks, Ghousein, Desplat, Dugot-Senant, Trézéguet, Sagliocco, Hagedorn, Grosset: "New tumor suppressor microRNAs target glypican-3 in human liver cancer." in: Oncotarget, Vol. 8, Issue 25, pp. 41211-41226, (2017) (PubMed).

Synonyms and alternative names related to Glypican 3

glypican 3 (gpc3), glypican 3 (GPC3), glypican 3 (Gpc3), dgsx, DGSX, Glypican-3, GPC3, GTR2-2, MXR7, oci-5, OCI-5, sdys, SDYS, sgb, SGB, sgbs, SGBS, sgbs1, SGBS1

Protein level used designations for Glypican 3

  • glypican 3
  • glypican-3-like
  • glypican proteoglycan 3
  • glypican-3
  • heparan sulphate proteoglycan
  • intestinal protein OCI-5
  • secreted glypican-3
  • defective in Simpson-Golabi-Behmel overgrowth syndrome
  • proteoglycan GPC3
  • Intestinal protein OCI-5
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