This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010].
Botermann, Brandes, Frommhold, Heß, Wolff, Zibat, Hahn, Buslei, Uhmann: "Hedgehog signaling in endocrine and folliculo-stellate cells of the adult pituitary." in: The Journal of endocrinology, (2021) (PubMed).