This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008].
Grimm, Hofstetter, Aust, Mutz-Dehbalaie, Bruch, Heinze, Rahhal-Schupp, Reinthaller, Concin, Polterauer: "Association of gamma-glutamyltransferase with severity of disease at diagnosis and prognosis of ovarian cancer." in: British journal of cancer, Vol. 109, Issue 3, pp. 610-4, (2013) (PubMed).