The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type\; brachydactyly, type C\; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. [provided by RefSeq, Jul 2008].
Yoon, Yang, Kim, Noh, Lee: "In Vitro Osteogenic Differentiation Enhanced by Zirconia Coated with Nano-Layered Growth and Differentiation Factor-5." in: Journal of nanoscience and nanotechnology, Vol. 16, Issue 1, pp. 280-6, (2016) (PubMed).
Shtaif, Dror, Bar-Maisels, Phillip, Gat-Yablonski: "Growth without growth hormone: can growth and differentiation factor 5 be the mediator?" in: Growth factors (Chur, Switzerland), Vol. 33, Issue 4, pp. 309-18, (2015) (PubMed).
Pei, Yang, Kiess, Sun, Luo: "Dynamic profile and adipogenic role of growth differentiation factor 5 (GDF5) in the differentiation of 3T3-L1 preadipocytes." in: Archives of biochemistry and biophysics, Vol. 560, pp. 27-35, (2014) (PubMed).
Bae, Ohe, Lee, Heo, Byun, Bae, Kwon, Kwon: "Photo-cured hyaluronic acid-based hydrogels containing growth and differentiation factor 5 (GDF-5) for bone tissue regeneration." in: Bone, Vol. 59, pp. 189-98, (2013) (PubMed).
Bae, Kim, Lee, Heo, Yang, Kim, Kwon, Bang, Bae, Kwon: "ZrO? surface chemically coated with hyaluronic acid hydrogel loading GDF-5 for osteogenesis in dentistry." in: Carbohydrate polymers, Vol. 92, Issue 1, pp. 167-75, (2012) (PubMed).