(gamma-aminobutyric Acid (GABA) A Receptor, epsilon (GABRE))
The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008].
Fatemi, Folsom, Rooney, Thuras: "Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder." in: Translational psychiatry, Vol. 3, pp. e303, (2013) (PubMed).
Hengen, Gomez, Stang, Johnson, Behan: "Changes in ventral respiratory column GABAaR ?- and ?-subunits during hibernation mediate resistance to depression by EtOH and pentobarbital." in: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 300, Issue 2, pp. R272-83, (2011) (PubMed).
Aliases for GABRE 抗体
gamma-aminobutyric acid type A receptor epsilon subunit (GABRE) 抗体 gamma-aminobutyric acid type A receptor epsilon subunit (Gabre) 抗体 gamma-aminobutyric acid (GABA) A receptor, subunit epsilon (Gabre) 抗体 GABRE 抗体