GABRA4 产品
(gamma-aminobutyric Acid (GABA) A Receptor, alpha 4 (GABRA4))
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Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011].
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Featured GABRA4 Categories
GABRA4 抗体
High quality antibodies with extensive validation data.
GABRA4 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
GABRA4 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GABRA4 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7153483
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN3181674
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN2565552
Quantity
100 μg
Datasheet
Datasheet
Recommended GABRA4 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6228561
Quantity
96 tests
Datasheet
Datasheet
Recommended GABRA4 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN2565117
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354651
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3080665
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our GABRA4 Products
: "Early growth response 1 (Egr-1) directly regulates GABAA receptor α2, α4, and θ subunits in the hippocampus." in: Journal of neurochemistry, Vol. 133, Issue 4, pp. 489-500, (2015) (PubMed).: "Downregulation of Gabra4 expression during alcohol withdrawal is mediated by specific microRNAs in cultured mouse cortical neurons." in: Brain and behavior, Vol. 5, Issue 8, pp. e00355, (2015) (PubMed).
: "Altered intrathalamic GABAA neurotransmission in a mouse model of a human genetic absence epilepsy syndrome." in: Neurobiology of disease, Vol. 73C, pp. 407-417, (2014) (PubMed).
: "Chronic ethanol and withdrawal differentially modulate lateral/basolateral amygdala paracapsular and local GABAergic synapses." in: The Journal of pharmacology and experimental therapeutics, Vol. 337, Issue 1, pp. 162-70, (2011) (PubMed).
: "Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells." in: The Journal of physiology, Vol. 589, Issue Pt 20, pp. 4959-80, (2011) (PubMed).
: "Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol." in: Addiction biology, Vol. 15, Issue 1, pp. 45-61, (2009) (PubMed).
: "Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones." in: The Journal of physiology, Vol. 586, Issue 4, pp. 965-87, (2008) (PubMed).
: "Alcohol regulates gene expression in neurons via activation of heat shock factor 1." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 47, pp. 12957-66, (2007) (PubMed).
: "Effect of chronic administration of ethanol on the regulation of tyrosine kinase phosphorylation of the GABAA receptor subunits in the rat brain." in: Neurochemical research, Vol. 32, Issue 7, pp. 1179-87, (2007) (PubMed).
: "Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA(A) receptor alpha4 subunit expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 33, pp. 11894-9, (2005) (PubMed).
Synonyms and alternative names related to GABRA4
gamma-aminobutyric acid type A receptor alpha4 subunit (GABRA4), gamma-aminobutyric acid type A receptor alpha4 subunit (Gabra4), gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 (Gabra4), Gabra-4, GABRA4Protein level used designations for GABRA4
- gamma-aminobutyric acid (GABA) A receptor, alpha 4
- gamma-aminobutyric acid A receptor, alpha 4
- GABA(A) receptor subunit alpha-4
- gamma-aminobutyric acid receptor subunit alpha-4-like
- GABA-A receptor alpha-4 subunit
- gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4
- gamma-aminobutyric acid receptor subunit alpha-4
- GABA(A) receptor, alpha 4
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