(Frequently Rearranged in Advanced T-Cell Lymphomas 2 (FRAT2))
The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008].
Saitoh, Moriwaki, Koike, Takagi, Miwa, Shiokawa, Katoh: "Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway." in: Biochemical and biophysical research communications, Vol. 281, Issue 3, pp. 815-20, (2001) (PubMed).