(Frequently Rearranged in Advanced T-Cell Lymphomas (FRAT1))
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008].
Yuan, Yang, Miao, Li, Liu, Zou: "The clinical significance of FRAT1 and ABCG2 expression in pancreatic ductal adenocarcinoma." in: Tumour biology, (2015) (PubMed).
Wang, Hewitt, Liu, Zhou, Zhu, Zhou, Zhang, Quan, Bai, Xu: "Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours." in: British journal of cancer, Vol. 94, Issue 5, pp. 686-91, (2006) (PubMed).
Hagen, Cross, Culbert, West, Frame, Morrice, Reith: "FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A." in: The Journal of biological chemistry, Vol. 281, Issue 46, pp. 35021-9, (2006) (PubMed).
Hino, Michiue, Asashima, Kikuchi: "Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 14066-73, (2003) (PubMed).
Aliases for FRAT1 抗体
FRAT1, WNT signaling pathway regulator (FRAT1) 抗体 GSK-3 binding protein FRAT1 (frat1) 抗体 frequently rearranged in advanced T cell lymphomas (Frat1) 抗体 frequently rearranged in advanced T-cell lymphomas (FRAT1) 抗体 frequently rearranged in advanced T-cell lymphomas 1 S homeolog (frat1.S) 抗体 AW060382 抗体 FRAT1 抗体 frat1 抗体 gbp 抗体