This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
custom-made
FOXO3
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
custom-made
FOXO3
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
Nott, Cheng, Gao, Lin, Gjoneska, Ko, Minhas, Zamudio, Meng, Zhang, Jin, Tsai: "Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior." in: Nature neuroscience, Vol. 19, Issue 11, pp. 1497-1505, (2016) (PubMed).
Thompson, Larson, Vidrine, Barrios, Navarro, Meyers, Simms, Prajapati, Chitsike, Hellman, Baker, Watkins: "FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 12, pp. 5637-47, (2015) (PubMed).
Lützner, Kalbacher, Krones-Herzig, Rösl: "FOXO3 is a glucocorticoid receptor target and regulates LKB1 and its own expression based on cellular AMP levels via a positive autoregulatory loop." in: PLoS ONE, Vol. 7, Issue 7, pp. e42166, (2012) (PubMed).