FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [provided by RefSeq, Jul 2008].
Boggetti, Argenton, Haffter, Bianchi, Cotelli, Beltrame: "Cloning and expression pattern of a zebrafish homolog of forkhead activin signal transducer (FAST), a transcription factor mediating Nodal-related signals." in: Mechanisms of development, Vol. 99, Issue 1-2, pp. 187-90, (2001) (PubMed).
Pogoda, Solnica-Krezel, Driever, Meyer: "The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of nodal signaling required for organizer formation." in: Current biology : CB, Vol. 10, Issue 17, pp. 1041-9, (2000) (PubMed).
Sirotkin, Gates, Kelly, Schier, Talbot: "Fast1 is required for the development of dorsal axial structures in zebrafish." in: Current biology : CB, Vol. 10, Issue 17, pp. 1051-4, (2000) (PubMed).