The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008].
Åström-Olsson, Li, Olofsson, Borén, Öhlin, Grip: "Impact of hypoxia, simulated ischemia and reperfusion in HL-1 cells on the expression of FKBP12/FKBP12.6 and intracellular calcium dynamics." in: Biochemical and biophysical research communications, Vol. 422, Issue 4, pp. 732-8, (2012) (PubMed).
Aliases for FKBP1B 蛋白
FK506 binding protein 1B (FKBP1B) 蛋白 FK506 binding protein 1B L homeolog (fkbp1b.L) 蛋白 FK506 binding protein 1B (fkbp1b) 蛋白 FK506 binding protein 1b (Fkbp1b) 蛋白 FK506 binding protein 1B (Fkbp1b) 蛋白 12.6kDa 蛋白 AW494148 蛋白 calstabin2 蛋白 DKFZp459K1429 蛋白 FKBP1B 蛋白 FKBP1L 蛋白 FKBP12.6 蛋白 MGC68829 蛋白 OTK4 蛋白 PKBP1L 蛋白 PPIase 蛋白