This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008].
Sharmin, Hamoh, Sigaeva, Mzyk, Damle, Morita, Vedelaar, Schirhagl: "Fluorescent Nanodiamonds for Detecting Free-Radical Generation in Real Time during Shear Stress in Human Umbilical Vein Endothelial Cells." in: ACS sensors, Vol. 6, Issue 12, pp. 4349-4359, (2022) (PubMed).
Jiang, Xu, Chen, Huang, Zhao, Zheng: "Impact of Hydrogel Elasticity and Adherence on Osteosarcoma Cells and Osteoblasts." in: Advanced healthcare materials, Vol. 8, Issue 9, pp. e1801587, (2020) (PubMed).
Ferizi, Leonhardt, Meggle, Aneja, Rudolph, Plank, Rädler: "Stability analysis of chemically modified mRNA using micropattern-based single-cell arrays." in: Lab on a chip, Vol. 15, Issue 17, pp. 3561-71, (2015) (PubMed).
Zhu, Gladson, White, Ding, Stewart, Jin, Chapman, Olman: "Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 297, Issue 1, pp. L97-108, (2009) (PubMed).
Reheman, Yang, Zhu, Jin, He, Spring, Bai, Gross, Freedman, Ni: "Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor." in: Blood, Vol. 113, Issue 8, pp. 1809-17, (2009) (PubMed).