This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Moresco, Speeckaert, Zmonarski, Krajewska, Komuda-Leszek, Perkowska-Ptasinska, Gesualdo, Rocchetti, Delanghe, Vanholder, Van Biesen, Delanghe: "Urinary myeloid IgA Fc alpha receptor (CD89) and transglutaminase-2 as new biomarkers for active IgA nephropathy and henoch-Schönlein purpura nephritis." in: BBA clinical, Vol. 5, pp. 79-84, (2016) (PubMed).
Matt, Lindqvist, Kleinau: "Elevated Membrane and Soluble CD64: A Novel Marker Reflecting Altered Fc?R Function and Disease in Early Rheumatoid Arthritis That Can Be Regulated by Anti-Rheumatic Treatment." in: PLoS ONE, Vol. 10, Issue 9, pp. e0137474, (2015) (PubMed).
Aliases for FCAR ELISA试剂盒
Fc fragment of IgA receptor (FCAR) ELISA试剂盒 Fc fragment of IgA, receptor for (FCAR) ELISA试剂盒 CD89 ELISA试剂盒