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FBXO32 产品

(F-Box Protein 32 (FBXO32))

Categories

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011].

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Featured FBXO32 Categories

FBXO32 抗体

High quality antibodies with extensive validation data.

FBXO32 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

FBXO32 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended FBXO32 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB
Validations
  • (5)
Cat. No. ABIN3017562
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN7251817
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (1)
  • (1)
Cat. No. ABIN747698
Quantity 100 μL
Datasheet Datasheet

Recommended FBXO32 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966624
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966625
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966626
Quantity 96 tests
Datasheet Datasheet

Recommended FBXO32 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1353808
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7408129
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3080206
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our FBXO32 Products

Zhou, Liu, Zhu, Ding, Wan, Li, Liu: "FBXO32 suppresses breast cancer tumorigenesis through targeting KLF4 to proteasomal degradation." in: Oncogene, Vol. 36, Issue 23, pp. 3312-3321, (2017) (PubMed).

Lin, Hanson, Betik, Brennan-Speranza, Hayes, Levinger: "Hindlimb Immobilization, But Not Castration, Induces Reduction of Undercarboxylated Osteocalcin Associated With Muscle Atrophy in Rats." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 31, Issue 11, pp. 1967-1978, (2016) (PubMed).

Lokireddy, McFarlane, Ge, Zhang, Sze, Sharma, Kambadur: "Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting." in: Molecular endocrinology (Baltimore, Md.), Vol. 25, Issue 11, pp. 1936-49, (2011) (PubMed).

Hanai, Cao, Tanksale, Imamura, Koshimizu, Zhao, Kishi, Yamashita, Phillips, Sukhatme, Lecker: "The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity." in: The Journal of clinical investigation, Vol. 117, Issue 12, pp. 3940-51, (2007) (PubMed).

Synonyms and alternative names related to FBXO32

F-box protein 32 (fbxo32), F-box protein 32 (FBXO32), F-box protein 32 (Fbxo32), 4833442G10Rik, AI430017, ATROGIN1, Atrogin1, Fbx32, Gm20361, MAFbx, MGC56479, zgc:56479

Protein level used designations for FBXO32

  • F-box only protein 32
  • atrogin-1
  • F-box protein 32
  • F-box only protein 32-like
  • atrogin 1
  • muscle atrophy F-box protein
  • atrophy gene 1
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