This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. [provided by RefSeq, Jul 2008].
Liu, Lear, Zhao, Zhao, Zou, Chen, Mallampalli: "F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7." in: Cell death & disease, Vol. 6, pp. e1630, (2015) (PubMed).
Liu, Lear, Iannone, Shiva, Corey, Rajbhandari, Jerome, Chen, Mallampalli: "The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin." in: The Journal of biological chemistry, Vol. 290, Issue 19, pp. 11843-52, (2015) (PubMed).
Aliases for FBXL7 抗体
F-box and leucine rich repeat protein 7 (FBXL7) 抗体 F-box and leucine-rich repeat protein 7 (Fbxl7) 抗体 AL023057 抗体 D230018M15Rik 抗体 FBL6 抗体 Fbl6 抗体 FBL7 抗体 FBXL7 抗体