(Family with Sequence Similarity 84, Member A (FAM84A))
Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA damage stimulus.
Wang, Xu, Qin, Wang, Ma, Luo, Zhang: "Myocardin-related transcription factor-A is a key regulator in retinoic acid-induced neural-like differentiation of adult bone marrow-derived mesenchymal stem cells." in: Gene, Vol. 523, Issue 2, pp. 178-86, (2013) (PubMed).
Aliases for FAM84A 抗体
family with sequence similarity 84, member A (Fam84a) 抗体 family with sequence similarity 84 member A (FAM84A) 抗体 family with sequence similarity 84, member A (fam84a) 抗体 family with sequence similarity 84 member A (Fam84a) 抗体 2310003N02Rik 抗体 4731402F03Rik 抗体 AW125753 抗体 Nse1 抗体 NSE1 抗体 PP11517 抗体 RGD1305779 抗体 zgc:63724 抗体