Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum (By similarity).
Anelli, Ceppi, Bergamelli, Cortini, Masciarelli, Valetti, Sitia: "Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis." in: The EMBO journal, Vol. 26, Issue 19, pp. 4177-88, (2007) (PubMed).