This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008].
Kitamura, Tange, Terasawa, Chiba, Kuwaki, Miyagawa, Piao, Miyazono, Urabe, Takaku: "Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin." in: Journal of cellular physiology, Vol. 140, Issue 2, pp. 323-34, (1989) (PubMed).
McDonald, Lin, Goldwasser: "Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene." in: Molecular and cellular biology, Vol. 6, Issue 3, pp. 842-8, (1986) (PubMed).
Shoemaker, Mitsock: "Murine erythropoietin gene: cloning, expression, and human gene homology." in: Molecular and cellular biology, Vol. 6, Issue 3, pp. 849-58, (1986) (PubMed).
JACOBSON, GOLDWASSER, FRIED, PLZAK: "Role of the kidney in erythropoiesis." in: Nature, Vol. 179, Issue 4560, pp. 633-4, (1957) (PubMed).
Aliases for EPO 蛋白
erythropoietin (EPO) 蛋白 erythropoietin (epo) 蛋白 erythropoietin S homeolog (epo.S) 蛋白 erythropoietin (Epo) 蛋白 erythropoietin a (epoa) 蛋白 EP 蛋白 EPO 蛋白 MVCD2 蛋白