The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009].
Horak, Tomasich, Vaňhara, Kratochvílová, Anees, Marhold, Lemberger, Gerschpacher, Horvat, Sibilia, Pils, Krainer: "TUSC3 loss alters the ER stress response and accelerates prostate cancer growth in vivo." in: Scientific reports, Vol. 4, pp. 3739, (2014) (PubMed).