Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008].
Majumdar, Kanafi, Bhonde, Gupta, Datta: "Differential Neuronal Plasticity of Dental Pulp Stem Cells From Exfoliated Deciduous and Permanent Teeth Towards Dopaminergic Neurons." in: Journal of cellular physiology, Vol. 231, Issue 9, pp. 2048-63, (2017) (PubMed).
Beltran, Graves, Blancafort: "Novel role of Engrailed 1 as a prosurvival transcription factor in basal-like breast cancer and engineering of interference peptides block its oncogenic function." in: Oncogene, Vol. 33, Issue 39, pp. 4767-77, (2014) (PubMed).
Veenvliet, Dos Santos, Kouwenhoven, von Oerthel, Lim, van der Linden, Koerkamp, Holstege, Smidt: "Specification of dopaminergic subsets involves interplay of En1 and Pitx3." in: Development (Cambridge, England), Vol. 140, Issue 16, pp. 3373-84, (2013) (PubMed).
Bachar-Dahan, Goltzmann, Yaniv, Gazit: "Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway." in: Molecular biology of the cell, Vol. 17, Issue 6, pp. 2572-80, (2006) (PubMed).