(Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2))
This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008].
Bidinosti, Martineau, Frank, Sonenberg: "Repair of isoaspartate formation modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain." in: The Journal of biological chemistry, Vol. 285, Issue 25, pp. 19402-8, (2010) (PubMed).
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).
Gingras, Sonenberg: "Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2." in: Virology, Vol. 237, Issue 1, pp. 182-6, (1997) (PubMed).
Aliases for eIF4EBP2 抗体
eukaryotic translation initiation factor 4E binding protein 2 (eif4ebp2) 抗体 eukaryotic translation initiation factor 4E binding protein 2 (Eif4ebp2) 抗体 eukaryotic translation initiation factor 4E binding protein 2 L homeolog (eif4ebp2.L) 抗体 eukaryotic translation initiation factor 4E binding protein 2 (EIF4EBP2) 抗体 eukaryotic initiation factor 4E (eIF-4E) 抗体 eukaryotic translation initiation factor 4E (Tb927.6.1870) 抗体 putative eukaryotic translation initiation factor 4e (LMJF_30_0450) 抗体 4E-BP2 抗体 4ebp2 抗体 4EBP2 抗体 2810011I19Rik 抗体 AA792569 抗体 BC010348 抗体 eIF-4E 抗体 EIF4EBP2 抗体 MGC75579 抗体 MGC78987 抗体 PHAS-II 抗体 PHASII 抗体 Tb06.28P18.1010 抗体 wu:fa55e11 抗体 wu:fp45e09 抗体