This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].
Huang, Yuan, Wan, Liu, Chen, Zhan, Li: "VE-statin/Egfl7 expression in malignant glioma and its relevant molecular network." in: International journal of clinical and experimental pathology, Vol. 7, Issue 3, pp. 1022-31, (2014) (PubMed).
Delfortrie, Pinte, Mattot, Samson, Villain, Caetano, Lauridant-Philippin, Baranzelli, Bonneterre, Trottein, Faveeuw, Soncin: "Egfl7 promotes tumor escape from immunity by repressing endothelial cell activation." in: Cancer research, Vol. 71, Issue 23, pp. 7176-86, (2011) (PubMed).
Badiwala, Tumiati, Joseph, Sheshgiri, Ross, Delgado, Rao: "Epidermal growth factor-like domain 7 suppresses intercellular adhesion molecule 1 expression in response to hypoxia/reoxygenation injury in human coronary artery endothelial cells." in: Circulation, Vol. 122, Issue 11 Suppl, pp. S156-61, (2010) (PubMed).