ECT2 抗体
(Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))
The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
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Latest Publications for our ECT2 抗体
: "Clinical significance of ECT2 expression in tissue and serum of gastric cancer patients." in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, Vol. 18, Issue 7, pp. 735-42, (2016) (PubMed).: "Elevated levels of epithelial cell transforming sequence 2 predicts poor prognosis for prostate cancer." in: Medical oncology (Northwood, London, England), Vol. 34, Issue 1, pp. 13, (2016) (PubMed).
: "Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner." in: The Journal of biological chemistry, Vol. 280, Issue 43, pp. 36502-9, (2005) (PubMed).
: "MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 37, pp. 13158-63, (2005) (PubMed).
: "The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis." in: The Journal of biological chemistry, Vol. 280, Issue 7, pp. 5733-9, (2005) (PubMed).
: "Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis." in: The Journal of cell biology, Vol. 147, Issue 5, pp. 921-8, (1999) (PubMed).
Aliases for ECT2 抗体
epithelial cell transforming 2 (ECT2) 抗体epithelial cell transforming 2 (ect2) 抗体
ect2 oncogene (Ect2) 抗体
epithelial cell transforming 2 S homeolog (ect2.S) 抗体
epithelial cell transforming 2 (Ect2) 抗体
AI528536 抗体
arhgef31 抗体
ARHGEF31 抗体
ECT2 抗体
ect2 抗体
mKIAA4037 抗体
xect2 抗体
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