EBV EBNA 3C 抗体
(Epstein-Barr Virus Nuclear Antigen-3C (EBNA-3C))
Plays an essential role for the efficient activation and immortalization of human B-cells by the virus. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA6 probably contributes to a negative autoregulatory control loop. Alternatively, EBNA6 also regulates the transcription of the EBV oncogene LMP1 in a cell cycle-dependent manner. Finally, EBNA6 modulates the activity of several host proteins involved in cell cycle regulation including host cyclin A, MYC, RB and p27 mainly through binding to the host SCF(SKP2) complex (By similarity).
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Recommended EBV EBNA 3C 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Epstein-Barr Virus (EBV)
Application
WB
Validations
Cat. No.
ABIN793565
Quantity
250 μg
Datasheet
Datasheet
Synonyms and alternative names related to EBV EBNA 3C
EBNA-3C (CeHV15gEBNA-3C), latency protein (HHV4tp2_gp30)Protein level used designations for EBV EBNA 3C
- EBNA-3C
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