This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011].
Moruzzo, Nobbio, Sterlini, Consalez, Benfenati, Schenone, Corradi: "The Transcription Factors EBF1 and EBF2 Are Positive Regulators of Myelination in Schwann Cells." in: Molecular neurobiology, (2016) (PubMed).
Nasrallah, Cho, Simonet, Putt, Kitamura, Golden: "Differential effects of a polyalanine tract expansion in Arx on neural development and gene expression." in: Human molecular genetics, Vol. 21, Issue 5, pp. 1090-8, (2012) (PubMed).
Bennett, Romigh, Eng: "Disruption of transforming growth factor-beta signaling by five frequently methylated genes leads to head and neck squamous cell carcinoma pathogenesis." in: Cancer research, Vol. 69, Issue 24, pp. 9301-5, (2009) (PubMed).
Aliases for EBF3 抗体
early B cell factor 3 (Ebf3) 抗体 early B-cell factor 3 (EBF3) 抗体 early B-cell factor 3 (Ebf3) 抗体 early B-cell factor 3 L homeolog (ebf3.L) 抗体 early B-cell factor 3a (ebf3a) 抗体 early B-cell factor 3 (ebf3) 抗体 3110018A08Rik 抗体 COE3 抗体 coe3 抗体 EBF-3 抗体 EBF3 抗体 mKIAA4201 抗体 O/E-2 抗体 OE-2 抗体 oe2 抗体 Xcoe3 抗体 xebf-3 抗体 Xebf3 抗体 zgc:158829 抗体