The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
Omelka, Martiniakova, Svik, Slovak, Payer, Oppenbergerova, Kovacova, Babikova, Soltesova-Prnova et al.: "The effects of eggshell calcium (Biomin H® ) and its combinations with alfacalcidol (1α-hydroxyvitamin D3) and menaquinone-7 (vitamin K2) on ovariectomy-induced bone loss in a rat model of ..." in: Journal of animal physiology and animal nutrition, Vol. 105, Issue 2, pp. 336-344, (2021) (PubMed).
Sananta, Jonatan, Ernanda, Kartikaningtyas, Parhusip, Amelia, Maulidya, Juwono: "Effects of nicotine on markers of bone turnover in ovariectomized rats." in: The Pan African medical journal, Vol. 33, pp. 37, (2019) (PubMed).
Deng, Kang, Zhao, Liu, Zhao: "Osteoprotective Effect of Echinocystic Acid, a Triterpone Component from Eclipta prostrata, in Ovariectomy-Induced Osteoporotic Rats." in: PLoS ONE, Vol. 10, Issue 8, pp. e0136572, (2016) (PubMed).
Vinoth, Patel, Lih, Seow, Cao, Meikle: "Appliance-induced osteopenia of dentoalveolar bone in the rat: effect of reduced bone strains on serum bone markers and the multifunctional hormone leptin." in: European journal of oral sciences, Vol. 121, Issue 6, pp. 517-24, (2013) (PubMed).
Sughis, Penders, Haufroid, Nemery, Nawrot: "Bone resorption and environmental exposure to cadmium in children: a cross--sectional study." in: Environmental health : a global access science source, Vol. 10, pp. 104, (2011) (PubMed).