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SCL (显示 TAL1 ELISA试剂盒)-LMO1 upregulated a stem cell gene signature in DN3 thymocytes.
Loss of Lmo1 repression may be one of the causes accounting for the phenotypic differences identified between the Arx((GCG)7)and Arx(432-455dup24) mouse models.
SCL (显示 TAL1 ELISA试剂盒), LMO1, and Notch1 (显示 NOTCH1 ELISA试剂盒) gain of function, together with an active pre-T-cell antigen receptor (显示 PTCRA ELISA试剂盒), might represent the minimum set of complementing events for the transformation of susceptible thymocytes into cancer cells
Results suggest that all four members of the LIM (显示 PDLIM5 ELISA试剂盒)-only family -- LMO1, 2, 3, and 4 -- are important regulators of distinct developmental pathways.
Lmo1 takes part in a Hox (显示 MSH2 ELISA试剂盒) paralogue 2-dependent network regulating anteroposterior and dorsoventral hindbrain patterning
These results suggested that LMO1 gene rs110419 A > G polymorphism may contribute to protection against neuroblastoma (显示 ARHGEF16 ELISA试剂盒)
A C-to-T single nucleotide transition occurs as a somatic mutation in noncoding sequences 4 kb upstream of the transcriptional start site of the LMO1 oncogene (显示 RAB1A ELISA试剂盒) in primary samples from patients with T-cell acute lymphoblastic leukaemia. This conforms to an APOBEC-like cytidine deaminase (显示 CDA ELISA试剂盒) mutational signature and a new MYB (显示 MYB ELISA试剂盒) binding site driving high levels of LMO1 expression.
LMO1 is an important oncogene (显示 RAB1A ELISA试剂盒) that promotes neuroblastoma (显示 ARHGEF16 ELISA试剂盒) initiation, progression, and widespread metastatic dissemination.
LMO1 appears to be a coactivator of AR involved in the progression of prostate cancer
data suggest that genetic variants in LMO1 are associated with increased NB risk in Chinese children.
a polymorphism within a super-enhancer element in the first intron of LMO1 influences neuroblastoma (显示 ARHGEF16 ELISA试剂盒) susceptibility through differential GATA (显示 QRSL1 ELISA试剂盒) transcription factor binding and direct modulation of LMO1 expression in cis (显示 CISH ELISA试剂盒)
LMO1 is a commonly activated tumor promoter that activates AKT (显示 AKT1 ELISA试剂盒) signaling in non-small cell lung cancer.
LMO1 is a commonly activated tumor promoter that activates AKT (显示 AKT1 ELISA试剂盒) signaling in colorectal cancer and a new predictive marker for targeted therapy.
results show that LMO1 is poised for expression in normal progenitors, where activation of SCL/TAL1 (显示 TAL1 ELISA试剂盒) together with a breakdown of epigenetic repression of LMO1 regulatory elements
genetic variants within LMO1 are associated with acute lymphoblastic leukemia and identify this gene as a strong candidate for precursor B-cell leukemogenesis.
This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions\; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described.
LIM domain only 1 (rhombotin 1)
, LIM domain only protein 1
, LIM only 1
, T-cell translocation protein 1
, cysteine-rich protein TTG-1
, LIM domain only protein 3
, LIM domain only 3
, neuronal-specific transcription factor DAT1
, dopamine-inducible LIM-domain transcription factor DAT1
, T-cell translocation gene 1
, rhombotin 1