This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010].
Johansson, Tabor, Wikell, Jalkanen, Fuxe: "TGF-β1-Induced Epithelial-Mesenchymal Transition Promotes Monocyte/Macrophage Properties in Breast Cancer Cells." in: Frontiers in oncology, Vol. 5, pp. 3, (2015) (PubMed).
Jabara, McDonald, Janssen, Massaad, Ramesh, Borzutzky, Rauter, Benson, Schneider, Baxi, Recher, Notarangelo, Wakim, Dbaibo, Dasouki, Al-Herz, Barlan, Baris, Kutukculer, Ochs, Plebani, Kanariou et al.: "DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. ..." in: Nature immunology, Vol. 13, Issue 6, pp. 612-20, (2012) (PubMed).