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DHX58 蛋白

(DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
DHX58 Protein (AA 1-678) (GST tag) DHX58 Protein (AA 1-678) (GST tag) DHX58 Protein (AA 1-678) (GST tag) (ABIN1351580)

DHX58 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP

DHX58 Protein (AA 1-678) (Strep Tag) DHX58 Protein (AA 1-678) (Strep Tag) DHX58 Protein (AA 1-678) (Strep Tag) (ABIN3092156)

Crystallography grade DHX58 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS

DHX58 Protein (AA 1-678) (Strep Tag) DHX58 Protein (AA 1-678) (Strep Tag) DHX58 Protein (AA 1-678) (Strep Tag) (ABIN3136923)

Crystallography grade DHX58 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS

DHX58 蛋白 by Grade

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DHX58 蛋白 by Origin

Find DHX58 蛋白 for a variety of species such as anti-Human DHX58, anti-Mouse DHX58. The species listed below are among those available. Click on a link to go to the corresponding products.

DHX58 蛋白 by Source

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DHX58 蛋白 by 蛋白类型

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DHX58 蛋白 by 应用范围

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Popular DHX58 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351580
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3092156
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3136923
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2719466
Quantity 20 μg
Datasheet Datasheet

Aliases for DHX58 蛋白

DEXH-box helicase 58 L homeolog (dhx58.L) 蛋白
DExH-box helicase 58 (DHX58) 蛋白
DExH-box helicase 58 (dhx58) 蛋白
probable ATP-dependent RNA helicase DHX58 (LOC100566102) 蛋白
DEXH (Asp-Glu-X-His) box polypeptide 58 (dhx58) 蛋白
DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58) 蛋白
DEXH-box helicase 58 (Dhx58) 蛋白
B430001I08Rik 蛋白
D11LGP2 蛋白
D11lgp2e 蛋白
D11Lgp2e 蛋白
DHX58 蛋白
lgp2 蛋白
LGP2 蛋白
Lgp2 蛋白
LPG2 蛋白
MGC82787 蛋白
RGD1310093 蛋白
RLR-3 蛋白
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