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DHX58 蛋白

(DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.

recommended

DHX58 Protein (AA 1-678) (GST tag) (ABIN1351580)

DHX58 宿主: 人宿主: 小麦胚 Recombinant ELISA, WB, AA, AP

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recommended

DHX58 Protein (AA 1-678) (Strep Tag) (ABIN3092156)

Crystallography grade DHX58 宿主: 人宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS

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recommended

DHX58 Protein (AA 1-678) (Strep Tag) (ABIN3136923)

Crystallography grade DHX58 宿主: 小鼠宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS

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DHX58 蛋白 by Grade

Find DHX58 蛋白 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

DHX58 蛋白 by Origin

Find DHX58 蛋白 for a variety of species such as anti-Human DHX58, anti-Mouse DHX58. The species listed below are among those available. Click on a link to go to the corresponding products.

DHX58 蛋白 by Source

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DHX58 蛋白 by 蛋白类型

Here you can find DHX58 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

DHX58 蛋白 by 应用范围

Find DHX58 蛋白 validated for a specific application such as ELISA, WB, SDS, AP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular DHX58 蛋白

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

DHX58 Protein (AA 1-678) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1351580

Quantity 10 μg

Datasheet Datasheet

DHX58 Protein (AA 1-678) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3092156

Quantity 1 mg

Datasheet Datasheet

DHX58 Protein (AA 1-678) (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3136923

Quantity 1 mg

Datasheet Datasheet

DHX58 Protein (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2719466

Quantity 20 μg

Datasheet Datasheet

Aliases for DHX58 蛋白

DEXH-box helicase 58 L homeolog (dhx58.L) 蛋白
DExH-box helicase 58 (DHX58) 蛋白
DExH-box helicase 58 (dhx58) 蛋白
probable ATP-dependent RNA helicase DHX58 (LOC100566102) 蛋白
DEXH (Asp-Glu-X-His) box polypeptide 58 (dhx58) 蛋白
DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58) 蛋白
DEXH-box helicase 58 (Dhx58) 蛋白
B430001I08Rik 蛋白
D11LGP2 蛋白
D11lgp2e 蛋白
D11Lgp2e 蛋白
DHX58 蛋白
lgp2 蛋白
LGP2 蛋白
Lgp2 蛋白
LPG2 蛋白
MGC82787 蛋白
RGD1310093 蛋白
RLR-3 蛋白

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DHX58 蛋白 by Grade

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Popular DHX58 蛋白

Aliases for DHX58 蛋白

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