Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.
Anderson, Quintero, Stover: "Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 37, pp. 15163-8, (2011) (PubMed).