This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].
Alcivar, Hu, Tang, Yang: "DEDD and DEDD2 associate with caspase-8/10 and signal cell death." in: Oncogene, Vol. 22, Issue 2, pp. 291-7, (2003) (PubMed).
Tibbetts, Zheng, Lenardo: "The death effector domain protein family: regulators of cellular homeostasis." in: Nature immunology, Vol. 4, Issue 5, pp. 404-9, (2003) (PubMed).
Roth, Stenner-Liewen, Pawlowski, Godzik, Reed: "Identification and characterization of DEDD2, a death effector domain-containing protein." in: The Journal of biological chemistry, Vol. 277, Issue 9, pp. 7501-8, (2002) (PubMed).
Aliases for DEDD2 抗体
death effector domain containing 2 (DEDD2) 抗体 death effector domain containing 2 L homeolog (dedd2.L) 抗体 death effector domain containing 2 (dedd2) 抗体 death effector domain-containing DNA binding protein 2 (Dedd2) 抗体 death effector domain containing 2 (Dedd2) 抗体 2410050E11Rik 抗体 DEDD2 抗体 FLAME-3 抗体 MGC145883 抗体