(Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008].
custom-made
DDB2
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
custom-made
DDB2
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
Robu, Shah, Petitclerc, BrindAmour, Kandan-Kulangara, Shah: "Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 5, pp. 1658-63, (2013) (PubMed).
Aliases for DDB2 蛋白
damage specific DNA binding protein 2 (DDB2) 蛋白 damage-specific DNA binding protein 2 (ddb2) 蛋白 damage specific DNA binding protein 2 (Ddb2) 蛋白 2610043A19Rik 蛋白 DDBB 蛋白 si:dkey-45f10.3 蛋白 UV-DDB2 蛋白