The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008].
Yoshizaki, Brito, Silva, Lino-Dos-Santos-Franco, Frias, E Silva, Amato-Lourenço, Saldiva, de Fátima Lopes Calvo Tibério, Mauad, Macchione: "The effects of particulate matter on inflammation of respiratory system: Differences between male and female." in: The Science of the total environment, Vol. 586, pp. 284-295, (2017) (PubMed).
Polat, Tunc, Erdem, Yerebasmaz, Tas, Beken, Basbozkurt, Saldir, Zenciroglu, Yaman: "Interleukin-8 and Its Receptors in Human Milk from Mothers of Full-Term and Premature Infants." in: Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, Vol. 11, pp. 247-51, (2017) (PubMed).