Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.
Contzler, Favre, Huber, Hohl: "Cornulin, a new member of the "fused gene" family, is expressed during epidermal differentiation." in: The Journal of investigative dermatology, Vol. 124, Issue 5, pp. 990-7, (2005) (PubMed).